TLR3 (CD283) Antibodies

Antibodies that detect TLR3 (CD283) can be used in several scientific applications, including Western Blot, Immunohistochemistry, Flow Cytometry, Immunocytochemistry and ELISA. These antibodies target TLR3 (CD283) in Human, Mouse, Rat, Canine and Porcine samples. Our TLR3 (CD283)... Antibodies that detect TLR3 (CD283) can be used in several scientific applications, including Western Blot, Immunohistochemistry, Flow Cytometry, Immunocytochemistry and ELISA. These antibodies target TLR3 (CD283) in Human, Mouse, Rat, Canine and Porcine samples. Our TLR3 (CD283) polyclonal, monoclonal and recombinant monoclonal... Antibodies that detect TLR3 (CD283) can be used in several scientific applications, including Western Blot, Immunohistochemistry, Flow Cytometry, Immunocytochemistry and ELISA. These antibodies target TLR3 (CD283) in Human, Mouse, Rat, Canine and Porcine samples. Our TLR3 (CD283) polyclonal, monoclonal and recombinant monoclonal antibodies are developed in Rabbit, Mouse and Rat. These antibodies have been verified by Cell treatment to confirm specificity to TLR3 (CD283). Find the TLR3 (CD283) antibody that fits your needs. Choose from 1 of 34 TLR3 (CD283) antibodies, which have been validated in experiments with 96 publications and 112 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF,... Antibodies that detect TLR3 (CD283) can be used in several scientific applications, including Western Blot, Immunohistochemistry, Flow Cytometry, Immunocytochemistry and ELISA. These antibodies target TLR3 (CD283) in Human, Mouse, Rat, Canine and Porcine samples. Our TLR3 (CD283) polyclonal, monoclonal and recombinant monoclonal antibodies are developed in Rabbit, Mouse and Rat. These antibodies have been verified by Cell treatment to confirm specificity to TLR3 (CD283). Find the TLR3 (CD283) antibody that fits your needs. Choose from 1 of 34 TLR3 (CD283) antibodies, which have been validated in experiments with 96 publications and 112 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you’re looking for, contact us today to develop custom antibodies for specific targets, species and applications.

Target Information

TLR3 (Toll-like receptor 3, CD283) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from drosophila to humans and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR3 is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. TLR3 recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. Further, TLR3 may play a role in host defense against viruses, and the use of alternative polyadenylation sites to generate different length transcripts has been noted for the TLR3 gene. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. TLR3 is the only human TLR which does not utilize MyD88 as an adaptor molecule instead utilizing TRIF in a signaling path which results in downstream activation of IRF-3 and NF-kB. TLR3 activation leads not only to Type I interferon induction but also to other inflammatory cytokines which result in DC maturation. TLR3 is known to recognize viral double-stranded (ds) RNA, a molecular pattern associated with viral infection. Recently it has been shown to recognize viruses such as Influenza A and West Nile Virus and can mediate entry of at least West Nile Virus.